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Article

Initiation of colorectal cancer: where do the two hits hit?

Cell cycle (Georgetown, Tex.) - 1 Dec 2004

Komarova Natalia L, Wang Liming

Abstract excerpt

It is widely believed that stem cells are of special importance for colorectal cancer initiation. The earliest event being the inactivation of both alleles of the Adenomatous Polyposis Coli (APC) gene, it is thought that the stem cells are the most likely target for these two first hits. Indeed,...

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Identifiers

PMID: 15611641
DOI: 10.4161/cc.3.12.1186

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15611641-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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