Article
Exhaustive genotyping of the CEM15 (APOBEC3G) gene and absence of association with AIDS progression in a French cohort.
The Journal of infectious diseases - 15 Jan 2005
Do Hervé, Vasilescu Alexandre, Diop Gora, Hirtzig Thomas, Heath Simon C, Coulonges Cédric, Rappaport Jay, Therwath Amu, Lathrop Mark, Matsuda Fumihiko, Zagury Jean-François
Abstract excerpt
CEM15 (or APOBEC3G) has recently been identified as an inhibitor of human immunodeficiency virus type 1 (HIV-1) replication in vitro. To evaluate the impact of its genetic variations on the progression of acquired immunodeficiency syndrome (AIDS), we have performed an extensive genetic analysis of CEM15. We have sequenced CEM15 in a cohort of 327 HIV-1-seropositive patients with extreme disease progression...
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