Article
Late viral RNA export, rather than p53 inactivation, determines ONYX-015 tumor selectivity.
Cancer cell - 1 Dec 2004
O'Shea Clodagh C, Johnson Leisa, Bagus Bridget, Choi Serah, Nicholas Cory, Shen Annie, Boyle Larry, Pandey Kusum, Soria Conrado, Kunich John, Shen Yuqiao, Habets Gaston, Ginzinger Dave, McCormick Frank
Abstract excerpt
ONYX-015 is an adenovirus that lacks the E1B-55K gene product for p53 degradation. Thus, ONYX-015 was conceived as an oncolytic virus that would selectively replicate in p53-defective tumor cells. Here we show that loss of E1B-55K leads to the induction, but not the activation, of p53 in ONYX-015-infected primary cells. We use a novel adenovirus mutant, ONYX-053, to demonstrate that loss of E1B-55K-mediated late...
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