Article
MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors.
Cancer cell - 1 Dec 2004
Huntly Brian J P, Shigematsu Hirokazu, Deguchi Kenji, Lee Benjamin H, Mizuno Shinichi, Duclos Nicky, Rowan Rebecca, Amaral Sonia, Curley David, Williams Ifor R, Akashi Koichi, Gilliland D Gary
Abstract excerpt
To better understand the origin of leukemic stem cells, we tested the hypothesis that all leukemia oncogenes could transform committed myeloid progenitor cells lacking the capacity for self-renewal, as has recently been reported for MLL-ENL. Flow-sorted populations of common myeloid progenitors and granulocyte-monocyte progenitors were transduced with the oncogenes MOZ-TIF2 and BCR-ABL, respectively....
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