Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Exploring biology with small organic molecules.

Nature - 16 Dec 2004

Stockwell Brent R

Abstract excerpt

Small organic molecules have proven to be invaluable tools for investigating biological systems, but there is still much to learn from their use. To discover and to use more effectively new chemical tools to understand biology, strategies are needed that allow us to systematically explore 'biological-activity space'. Such strategies involve analysing both protein binding of, and phenotypic responses to, small...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biology
Share to Drug Evaluation, Preclinical
Share to Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Binding

Share to Substrate Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 15602550
DOI: 10.1038/nature03196
PMCID: PMC3165172

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Exploring biology with small organic molecules.PMID 15602550Read ↗

Chemical space and biologySemantic proximity Read ↗

Small molecules as geneticists.Semantic proximity Read ↗

Opportunities at the interface of chemistry and biology.Semantic proximity Read ↗

Chemical genetics: elucidating biological systems with small-molecule compounds.Semantic proximity Read ↗

From Knowing to Controlling: A Path from Genomics to Drugs Using Small Molecule ProbesSemantic proximity Read ↗

Connecting synthetic chemistry decisions to cell and genome biology using small-molecule phenotypic profiling.Semantic proximity Read ↗

The why and how of phenotypic small-molecule screens.Semantic proximity Read ↗

Small Molecule Probes of Cellular Pathways and NetworksSemantic proximity Read ↗

From Phenotypic Hit to Chemical Probe: Chemical Biology Approaches to Elucidate Small Molecule Action in Complex Biological Systems.Semantic proximity Read ↗

Zebrafish-based small molecule discovery.Semantic proximity Read ↗

Target identification and mechanism of action in chemical biology and drug discovery.Semantic proximity Read ↗

Identification of protein binding partners of small molecules using label-free methods.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.