Article
A pairing-sensitive element that mediates trans-inactivation is associated with the Drosophila brown gene.
Genes & development - 1 Mar 1991
Dreesen T D, Henikoff S, Loughney K
Abstract excerpt
Position-effect variegation in Drosophila is the mosaic expression of a gene juxtaposed to heterochromatin by chromosome rearrangement. The brown (bw+) gene is unusual in that variegating mutations are dominant, causing "trans-inactivation" of the homologous allele. We show that copies of bw+ transposed to ectopic sites are not trans-inactivated by rearrangements affecting the endogenous gene. However, when...
Topics
- Animals
- Chromosome Aberrations
- Chromosome Mapping
- DNA Transposable Elements
- Drosophila melanogaster
- Gene Expression Regulation
- Genes
- Male
- Mutation
- Suppression, Genetic
- Transcription, Genetic