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Article

Eighteenth century Yersinia pestis genomes reveal the long-term persistence of an historical plague focus.

eLife - 21 Jan 2016

Bos Kirsten I, Herbig Alexander, Sahl Jason, Waglechner Nicholas, Fourment Mathieu, Forrest Stephen A, Klunk Jennifer, Schuenemann Verena J, Poinar Debi, Kuch Melanie, Golding G Brian, Dutour Olivier, Keim Paul, Wagner David M, Holmes Edward C, Krause Johannes, Poinar Hendrik N

Abstract excerpt

The 14th-18th century pandemic of Yersinia pestis caused devastating disease outbreaks in Europe for almost 400 years. The reasons for plague's persistence and abrupt disappearance in Europe are poorly understood, but could have been due to either the presence of now-extinct plague foci in Europe itself, or successive disease introductions from other locations. Here we present five Y. pestis genomes from one of...

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Identifiers

PMID: 26795402
DOI: 10.7554/eLife.12994
PMCID: PMC4798955

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