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Article

Charge and hydrophobicity patterning along the sequence predicts the folding mechanism and aggregation of proteins: a computational approach.

Journal of proteome research - 1 Jan 2000

Zbilut Joseph P, Giuliani Alessandro, Colosimo Alfredo, Mitchell Julie C, Colafranceschi Mauro, Marwan Norbert, Webber Charles L, Uversky Vladimir N

Abstract excerpt

The presence of partially folded intermediates along the folding funnel of proteins has been suggested to be a signature of potentially aggregating systems. Many studies have concluded that metastable, highly flexible intermediates are the basic elements of the aggregation process. In a previous paper, we demonstrated how the choice between aggregation and folding behavior was influenced by hydrophobicity...

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Identifiers

PMID: 15595734
DOI: 10.1021/pr049883+

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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