Article
Treatment of MDS patients with recombinant human erythropoietin and the role of GSTs.
Journal of experimental & clinical cancer research : CR - 1 Sept 2004
Tsabouri S E, Georgiou I, Katsaraki A, Bourantas K L
Abstract excerpt
Glutathione S-transferases (GSTs) are a group of enzymes involved in the detoxification process of carcinogens and other substances. The genes encoding isoenzymes M1 and T1 have "null" alleles, which are polymorphic in humans. Our purpose was to examine whether the GSTM1 and GSTT1 homozygous null genotypes have an impact on the response to recombinant human erythropoietin (rhuEpo) treatment in MDS patients. We...
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