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Article

Formation of the retinotectal projection requires Esrom, an ortholog of PAM (protein associated with Myc).

Development (Cambridge, England) - 1 Jan 2005

D'Souza Jasmine, Hendricks Michael, Le Guyader Sylvie, Subburaju Sivan, Grunewald Barbara, Scholich Klaus, Jesuthasan Suresh

Abstract excerpt

Visual system development is dependent on correct interpretation of cues that direct growth cone migration and axon branching. Mutations in the zebrafish esrom gene disrupt bundling and targeting of retinal axons, and also cause ectopic arborization. By positional cloning, we establish that esrom encodes a very large protein orthologous to PAM (protein associated with Myc)/Highwire/RPM-1. Unlike motoneurons in...

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Identifiers

PMID: 15590740
DOI: 10.1242/dev.01578

Genes

PAM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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