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Article

Pam and its ortholog highwire interact with and may negatively regulate the TSC1.TSC2 complex.

The Journal of biological chemistry - 9 Jan 2004

Murthy Vanishree, Han Sangyeul, Beauchamp Roberta L, Smith Nicole, Haddad Luciana A, Ito Naoto, Ramesh Vijaya

Abstract excerpt

Tuberous Sclerosis Complex (TSC) is an autosomal dominant disorder associated with mutations in TSC1, which codes for hamartin, or TSC2, which codes for tuberin. The brain is one of the most severely affected organs, and CNS lesions include cortical tubers and subependymal giant cell astrocytomas, resulting in mental retardation and seizures. Tuberin and hamartin function together as a complex in mammals and...

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Source

Identifiers

PMID: 14559897
DOI: 10.1074/jbc.M310208200

Genes

TSC1
TSC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pam and its ortholog highwire interact with and may negatively regulate the TSC1.TSC2 complex.PMID 14559897Read ↗

The E3 Ubiquitin Ligase Protein Associated with Myc (Pam) Regulates Mammalian/Mechanistic Target of Rapamycin Complex 1 (mTORC1) Signaling in Vivo through N- and C-terminal DomainsSemantic proximity Read ↗

The tuberous sclerosis gene products hamartin and tuberin are multifunctional proteins with a wide spectrum of interacting partnersSemantic proximity Read ↗

Hamartin, the tuberous sclerosis complex 1 gene product, interacts with polo-like kinase 1 in a phosphorylation-dependent manner.Semantic proximity Read ↗

Proteins interacting with the tuberous sclerosis gene products.Semantic proximity Read ↗

Interaction between hamartin and tuberin, the TSC1 and TSC2 gene productsSemantic proximity Read ↗

The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitinationSemantic proximity Read ↗

Loss-of-function variants in MYCBP2 cause neurobehavioural phenotypes and corpus callosum defects.Semantic proximity Read ↗

The TSC1 tumor suppressor hamartin interacts with neurofilament-L and possibly functions as a novel integrator of the neuronal cytoskeleton.Semantic proximity Read ↗

Drosophila Rae1 controls the abundance of the ubiquitin ligase Highwire in post-mitotic neurons.Semantic proximity Read ↗

Tuberin and hamartin are aberrantly expressed and linked to clinical outcome in human breast cancer: The role of promoter methylation of TSC genesSemantic proximity Read ↗

Cellular and molecular determinants targeting the Caenorhabditis elegans PHR protein RPM-1 to perisynaptic regions.Semantic proximity Read ↗

The TSC1 gene product, hamartin, negatively regulates cell proliferationSemantic proximity Read ↗

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