Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Endothelial–Mesenchymal Interactions In Vitro Reveal Molecular Mechanisms of Smooth Muscle/Pericyte Differentiation

1 Oct 2004

Abstract excerpt

Cell-cell interactions are central to vascular development. We have developed an in vitro system in which endothelial cells (EC) are co-cultured with 10T1/2 cells as smooth muscle cell (SMC)/pericyte precursors. 10T1/2 cells, in contact with EC, differentiate to SMC in a process mediated, at least in part, by a transforming growth factor-beta (TGF-beta)-mediated event. Co-culture with EC or TGF-beta treatment...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Angiogenesis and VEGF in Cancer
Share to Cerebrovascular and genetic disorders
Share to TGF-β signaling in diseases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15588508
DOI: 10.1089/scd.2004.13.509

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Endothelial–Mesenchymal Interactions In Vitro Reveal Molecular Mechanisms of Smooth Muscle/Pericyte DifferentiationPMID 15588508Read ↗

PDGF, TGF-beta, and heterotypic cell-cell interactions mediate endothelial cell-induced recruitment of 10T1/2 cells and their differentiation to a smooth muscle fate.Semantic proximity Read ↗

Endothelial cell activation of the smooth muscle cell phosphoinositide 3-kinase/Akt pathway promotes differentiation.Semantic proximity Read ↗

Coculture conditions alter endothelial modulation of TGF-β1 activation and smooth muscle growth morphologySemantic proximity Read ↗

A system for the direct co-culture of endothelium on smooth muscle cells.Semantic proximity Read ↗

Co‐culture of endothelial cells and smooth muscle cells affects gene expression of angiogenic factorsSemantic proximity Read ↗

Angiopoietin 1, PDGF‐B, and TGF‐β gene regulation in endothelial cell and smooth muscle cell interactionSemantic proximity Read ↗

Smooth muscle cells and myofibroblasts use distinct transcriptional mechanisms for smooth muscle alpha-actin expression.Semantic proximity Read ↗

Endothelial progenitor cells undergo an endothelial-to-mesenchymal transition-like process mediated by TGFbetaRI.Semantic proximity Read ↗

Signaling mechanisms that regulate smooth muscle cell differentiation.Semantic proximity Read ↗

Tightening of endothelial cell contacts: a physiologic response to cocultures with smooth-muscle-like 10T1/2 cells.Semantic proximity Read ↗

Cooperative binding of KLF4, pELK-1, and HDAC2 to a G/C repressor element in the SM22α promoter mediates transcriptional silencing during SMC phenotypic switching in vivo.Semantic proximity Read ↗

Smooth muscle cell differentiation in vitro: models and underlying molecular mechanisms.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.