Article
Tightening of endothelial cell contacts: a physiologic response to cocultures with smooth-muscle-like 10T1/2 cells.
The Journal of investigative dermatology - 1 Jul 2002
Kurzen Hjalmar, Manns Sabine, Dandekar Gudrun, Schmidt Tim, Prätzel Silke, Kräling Birgit Maria
Abstract excerpt
Tightening of endothelial cell-to-cell contacts is an important event at the end of angiogenesis in order to achieve controlled transfer of solutes between the blood stream and solid tissues. We found that tightening of endothelial cell-to-cell contacts and the formation of a permeability barrier can be induced in vitro by dibutyryl cAMP and hydrocortisone. This process is accompanied by increased junctional...
Topics
- Adherens Junctions
- Anti-Inflammatory Agents
- Bucladesine
- Capillary Permeability
- Cell Communication
- Cell Differentiation
- Coculture Techniques
- Connexins
- Cytoskeleton
- Dermis
- Endothelium, Vascular
- Humans
- Hydrocortisone
- Muscle, Smooth, Vascular