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Article

Apigenin induces cell cycle arrest and p21/WAF1 expression in a p53-independent pathway.

International journal of oncology - 1 Jan 2005

Takagaki Nobumasa, Sowa Yoshihiro, Oki Teruki, Nakanishi Ryoko, Yogosawa Shingo, Sakai Toshiyuki

Abstract excerpt

Apigenin, a common dietary flavonoid, has been shown to induce cell growth-inhibition and cell cycle arrest in many cancer cell lines. One important effect of apigenin is to increase the stability of the tumor suppressor p53 in normal cells. Therefore, apigenin is expected to play a large role in...

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Identifiers

PMID: 15586239

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15586239-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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