Molecular mechanisms for apigenin‐induced cell‐cycle arrest and apoptosis of hormone refractory human prostate carcinoma DU145 cells

Abstract excerpt

Development of effective agents for treatment of hormone-refractory prostate cancer has become a national medical priority. We have reported recently that apigenin (4',5,7-trihydroxyflavone), found in many common fruits and vegetables, has shown remarkable effects in inhibiting cell growth and inducing apoptosis in many human prostate carcinoma cells. Here we demonstrate the molecular mechanism of inhibitory...

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