Article
Long-term outcomes of bariatric surgery in patients with bi-allelic mutations in the POMC, LEPR, and MC4R genes.
Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery - 1 Aug 2021
Poitou Christine, Puder Lia, Dubern Beatrice, Krabusch Philipp, Genser Laurent, Wiegand Susanna, Verkindt Hélène, Köhn Arvid, von Schwartzenberg Reiner Jumpertz, Flück Christa, Pattou François, Laville Martine, Kühnen Peter, Clément Karine
Abstract excerpt
BACKGROUND: Gene mutations in the leptin-melanocortin signaling cascade lead to hyperphagia and severe early onset obesity. In most cases, multimodal conservative treatment (increased physical activity, reduced caloric intake) is not successful to stabilize body weight and control hyperphagia. OBJECTIVES: To examine bariatric surgery as a therapeutic option for patients with genetic obesity. SETTING: Three major...
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