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Article

Genetic correction of canine dystrophic epidermolysis bullosa mediated by retroviral vectors

21 Jul 2003

Abstract excerpt

We have assessed the suitability of retroviral vectors for gene therapy of recessive dystrophic epidermolysis bullosa (RDEB) in dogs expressing a mutated collagen type VII. Isolation and analysis of the 9 kb dog collagen type VII cDNA identified the causative genetic mutation G1906S and disclosed the interspecies conservation of collagen type VII. Highly efficient transfer of the wild-type collagen type VII cDNA...

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PMID: 12874109
DOI: 10.1093/hmg/ddg200

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Source receipt: pubmed, retrieved 7 Sept 2026.

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