Article
Genetic diversity and antigenic polymorphism in Plasmodium falciparum: extensive serological cross-reactivity between allelic variants of merozoite surface protein 2.
Infection and immunity - 1 Jun 2003
Franks Simon, Baton Luke, Tetteh Kevin, Tongren Eric, Dewin David, Akanmori Bartholomew D, Koram Kojo A, Ranford-Cartwright Lisa, Riley Eleanor M
Abstract excerpt
Diversity in the surface antigens of malaria parasites is generally assumed to be a mechanism for immune evasion, but there is little direct evidence that this leads to evasion of protective immunity. Here we show that alleles of the highly polymorphic merozoite surface protein 2 (MSP-2) can be grouped (within the known dimorphic families) into distinct serogroups; variants within a serogroup show extensive...
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