Article
Strain-transcending Fc-dependent killing of Plasmodium falciparum by merozoite surface protein 2 allele-specific human antibodies.
Infection and immunity - 1 Mar 2011
Stubbs Janine, Olugbile Sope, Saidou Balam, Simpore Jacques, Corradin Giampietro, Lanzavecchia Antonio
Abstract excerpt
It is widely accepted that antibody responses against the human parasitic pathogen Plasmodium falciparum protect the host from the rigors of severe malaria and death. However, there is a continuing need for the development of in vitro correlate assays of immune protection. To this end, the capacity of human monoclonal and polyclonal antibodies in eliciting phagocytosis and parasite growth inhibition via Fcγ...
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