Article
A mutation in serca underlies motility dysfunction in accordion zebrafish.
Developmental biology - 15 Dec 2004
Gleason Michelle R, Armisen Ricardo, Verdecia Mark A, Sirotkin Howard, Brehm Paul, Mandel Gail
Abstract excerpt
Zebrafish acquire the ability for fast swimming early in development. The motility mutant accordion (acc) undergoes exaggerated and prolonged contractions on both sides of the body, interfering with the acquisition of patterned swimming responses. Our whole cell recordings from muscle indicate that the defect is not manifested in neuromuscular transmission. However, imaging of skeletal muscle of larval acc...
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