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Article

CpG methylation of the FHIT, FANCF, cyclin-D2, BRCA2 and RUNX3 genes in Granulosa cell tumors (GCTs) of ovarian origin.

1 Jan 2004

Abstract excerpt

BACKGROUND: Granulosa cell tumors (GCTs) are relatively rare and are subtypes of the sex-cord stromal neoplasms. Methylation induced silencing in the promoters of genes such as tumor suppressor genes, DNA repair genes and pro-apoptotic genes is recognised as a critical factor in cancer development. METHODS: We examined the role of promoter hypermethylation, an epigenetic alteration that is associated with the...

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Share to Epigenetics and DNA Methylation
Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Share to Ovarian cancer diagnosis and treatment

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PMID: 15574200
DOI: 10.1186/1476-4598-3-33

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