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Article

Hypermethylation of CDH13, DKK3 and FOXL2 promoters and the expression of EZH2 in ovary granulosa cell tumors.

Molecular medicine reports - 1 Sept 2016

Xu Yanmei, Li Xia, Wang Hongtao, Xie Pengmu, Yan Xun, Bai Yu, Zhang Tingguo

Abstract excerpt

Aberrant epigenetic modification is associated with the development and progression of cancer. Hypermethylation of tumor suppressor gene promoters and cooperative histone modification have been considered to be the primary mechanisms of epigenetic modification. Ovary granulosa cell tumors (GCTs) are relatively rare, accounting for ~3% of all ovarian malignancies. The present study assessed hypermethylation of the...

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Source

Identifiers

PMID: 27431680
DOI: 10.3892/mmr.2016.5521

Genes

CDH13
DKK3
FOXL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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