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Article

Beta-globin nonsense mutation: deficient accumulation of mRNA occurs despite normal cytoplasmic stability.

Proceedings of the National Academy of Sciences of the United States of America - 1 Apr 1992

Baserga S J, Benz E J

Abstract excerpt

A common mutation causing thalassemia in Mediterranean populations is an amber (UAG) nonsense mutation at the 39th codon of the human beta-globin gene, the beta-39 mutation. Studies of mRNA metabolism in erythroblasts from patients with beta-39 thalassemia and studies using heterologous transfection systems have suggested the possibility that this mutation not only affects protein synthesis but also alters mRNA...

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Identifiers

PMID: 1557399
DOI: 10.1073/pnas.89.7.2935
PMCID: PMC48778

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Beta-globin nonsense mutation: deficient accumulation of mRNA occurs despite normal cytoplasmic stability.PMID 1557399Read ↗

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