Article
The directed mutation controversy and neo-Darwinism.
Science (New York, N.Y.) - 8 Jan 1993
Lenski R E, Mittler J E
Abstract excerpt
According to neo-Darwinian theory, random mutation produces genetic differences among organisms whereas natural selection tends to increase the frequency of advantageous alleles. However, several recent papers claim that certain mutations in bacteria and yeast occur at much higher rates specifically when the mutant phenotypes are advantageous. Various molecular models have been proposed that might explain these...
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