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Cell cycle-arrested tumor cells exhibit increased sensitivity towards TRAIL-induced apoptosis

6 Jun 2013

Abstract excerpt

Resting tumor cells represent a huge challenge during anticancer therapy due to their increased treatment resistance. TNF-related apoptosis-inducing ligand (TRAIL) is a putative future anticancer drug, currently in phases I and II clinical studies. We recently showed that TRAIL is able to target leukemia stem cell surrogates. Here, we tested the ability of TRAIL to target cell cycle-arrested tumor cells. Cell...

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PMID: 23744361
DOI: 10.1038/cddis.2013.179

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