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Article

Amino acid differences in the deduced 5-lipoxygenase sequence of CAST atherosclerosis-resistance mice confer impaired activity when introduced into the human ortholog.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2003

Kuhn Hartmut, Anton Monika, Gerth Christa, Habenicht Andreas

Abstract excerpt

OBJECTIVE: The mouse strain CON6, which was generated by breeding athero-resistant CAST mice into an athero-susceptible B6 background, exhibits almost complete resistance to atherosclerosis. An athero-resistance gene cluster has been localized at the central region of chromosome 6, and among the candidate genes of this locus, the 5-lipoxygenase has attracted particular attention because of its involvement in the...

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PMID: 12730086
DOI: 10.1161/01.ATV.0000074167.01184.48

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CAST

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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