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Nucleolar Localization of Human Hepatitis B Virus Capsid Protein

24 Nov 2004

Abstract excerpt

Wild-type human hepatitis B virus (HBV) exhibits selective export of virions containing mature genomes. In contrast, changing an isoleucine to a leucine at amino acid 97 (I97L) of the HBV core antigen (HBcAg) causes it to release immature genomes. To elucidate the structure-function relationship of HBcAg at amino acid 97, we systematically replaced the isoleucine residue at this position with 18 other amino acids...

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PMID: 15564475
DOI: 10.1128/jvi.78.24.13653-13668.2004

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