Article
Prediction of the risk of type 1 diabetes from polymorphisms in candidate genes.
Diabetes research and clinical practice - 1 Dec 2004
Park Y
Abstract excerpt
Type 1 diabetes (T1D) is a T-cell-mediated autoimmune disease, in which pancreatic beta cells are selectively destroyed. Innate immune response is also important in the development of T1D. Several studies have demonstrated that HLA class II alleles, DQ and DR influence T1D susceptibility. Specific class I and II alleles are non-randomly associated with each other on an extended haplotypes, the typing of which...
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