Article
Notch signals inhibit the development of erythroid/megakaryocytic cells by suppressing GATA-1 activity through the induction of HES1.
The Journal of biological chemistry - 11 Feb 2005
Ishiko Eri, Matsumura Itaru, Ezoe Sachiko, Gale Karin, Ishiko Jun, Satoh Yusuke, Tanaka Hirokazu, Shibayama Hirohiko, Mizuki Masao, Era Takumi, Enver Tariq, Kanakura Yuzuru
Abstract excerpt
The effects of Notch signals on the erythroid/megakaryocytic differentiation of hematopoietic cells were examined. Activation of Notch signals by the intracellular Notch1 or an estradiol-inducible form of Notch1/ER suppressed the expression of the erythroid marker glycophorin A in an erythroid/megakaryocytic cell line K562. Although Mock-transfected K562 cells underwent megakaryocytic differentiation in response...
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