Article
Glial cell line-derived neurotrophic factor (GDNF) is required for differentiation of pontine noradrenergic neurons and patterning of central respiratory output.
Neuroscience - 1 Jan 2005
Huang L, Guo H, Hellard D T, Katz D M
Abstract excerpt
Genetic mutations affecting signaling by glial cell line-derived neurotrophic factor (GDNF) perturb development of breathing in mice and are associated with congenital central hypoventilation syndrome in humans. However, the role of GDNF in development of brainstem neurons that control breathing is largely unknown. The present study demonstrates that genetic loss of GDNF decreases the number of tyrosine...
Topics
- Age Factors
- Analysis of Variance
- Animals
- Antibodies
- Brain-Derived Neurotrophic Factor
- Cell Count
- Cell Differentiation
- Cell Size
- Cells, Cultured
- Choline O-Acetyltransferase
- Drug Interactions