Article
MASH-1/RET pathway involvement in development of brain stem control of respiratory frequency in newborn mice.
Physiological genomics - 21 Dec 2001
Dauger S, Guimiot F, Renolleau S, Levacher B, Boda B, Mas C, Nepote V, Simonneau M, Gaultier C, Gallego J
Abstract excerpt
Respiratory abnormalities have been described in MASH-1 (mammalian achaete-scute homologous gene) and c-RET ("rearranged during transfection") mutant newborn mice. However, the neural mechanisms underlying these abnormalities have not been studied. We tested the hypothesis that the MASH-1 mutation may impair c-RET expression in brain stem neurons involved in the control of breathing. To do this, we analyzed brain...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.