Article
His239Arg SNP of HRAD9 is associated with lung adenocarcinoma.
Cancer - 1 Mar 2006
Maniwa Yoshimasa, Yoshimura Masahiro, Bermudez Vladimir P, Okada Kenji, Kanomata Naoki, Ohbayashi Chiho, Nishimura Yoshihiro, Hayashi Yoshitake, Hurwitz Jerard, Okita Yutaka
Abstract excerpt
BACKGROUND: It was previously reported that a functional human (h) Rad9 protein accumulated in the nuclei of non-small cell lung carcinoma (NSCLC) cells. Those experiments, however, did not examine whether the hRad9 gene was mutated in those cells. The sequence of the HRAD9 gene in NSCLC cells was investigated. METHODS: The sequence of the HRAD9 was examined in tumor and peripheral normal lung tissues obtained...
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