<i>Rhodococcus equi</i> -Infected Macrophages Are Recognized and Killed by CD8 ⁺ T Lymphocytes in a Major Histocompatibility Complex Class I-Unrestricted Fashion

Abstract excerpt

The goal of this research was to examine the role of cytotoxic T lymphocytes (CTL) in the control of Rhodococcus equi and specifically to determine if R. equi-specific CD8+ CTL occurred in the blood of immune horses. Equine peripheral blood mononuclear cells stimulated with antigen-presenting cells either infected with R. equi or exposed to soluble R. equi antigen lysed R. equi-infected target cells. Lysis was...

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