Article
Atg21p is essential for macropexophagy and microautophagy in the yeast Hansenula polymorpha.
FEBS letters - 19 Nov 2004
Leão-Helder Adriana N, Krikken Arjen M, Gellissen Gerd, van der Klei Ida J, Veenhuis Marten, Kiel Jan A K W
Abstract excerpt
ATG genes are required for autophagy-related processes that transport proteins/organelles destined for proteolytic degradation to the vacuole. Here, we describe the identification and characterisation of the Hansenula polymorpha ATG21 gene. Its gene product Hp-Atg21p, fused to eGFP, had a dual location in the cytosol and in peri-vacuolar dots. We demonstrate that Hp-Atg21p is essential for two separate modes of...
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