Article
A peroxisomal lon protease and peroxisome degradation by autophagy play key roles in vitality of Hansenula polymorpha cells.
Autophagy - 1 Jan 2000
Aksam Eda Bener, Koek Anne, Kiel Jan A K W, Jourdan Stefanie, Veenhuis Marten, van der Klei Ida J
Abstract excerpt
In eukaryote cells various mechanisms exist that are responsible for the removal of non-functional proteins. Here we show that in the yeast Hansenula polymorpha (H. polymorpha) a peroxisomal Lon protease, Pln, plays a role in degradation of unfolded and non-assembled peroxisomal matrix proteins. In addition, we demonstrate that whole peroxisomes are constitutively degraded by autophagy during normal vegetative...
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