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Article

Hepatitis B virus mutations associated with antiviral therapy.

Journal of medical virology - 1 Jan 2006

Bartholomeusz A, Locarnini S

Abstract excerpt

The hepatitis B virus (HBV) replicates via an error prone viral reverse transcriptase resulting in a large pool of quasispecies with mutations spread throughout the genome. During antiviral drug selection pressure (e.g., lamivudine, adefovir, or entecavir) HBV mutants are selected from the pre-existing pool of quasispecies and over time become the dominant species. Not all mutations result in replication...

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Share to Antiviral Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16622878
DOI: 10.1002/jmv.20608

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