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Article

Mutations affecting the replication capacity of the hepatitis B virus.

Journal of viral hepatitis - 1 Jul 2006

Sheldon J, Rodès B, Zoulim F, Bartholomeusz A, Soriano V

Abstract excerpt

The genetic variability of the hepatitis B virus (HBV) encounters two compounding forces: a high viral copy number produced during active replication and the lack of proofreading activity in the HBV polymerase, resulting in a high mutational rate. A large pool of quasispecies is generated in which the fittest virus, i.e. the virus that replicates best, becomes the dominant species. Immune and antiviral selection...

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Identifiers

PMID: 16792535
DOI: 10.1111/j.1365-2893.2005.00713.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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