Article
Mast cells promote homeostasis by limiting endothelin-1-induced toxicity.
Nature - 25 Nov 2004
Maurer Marcus, Wedemeyer Jochen, Metz Martin, Piliponsky Adrian M, Weller Karsten, Chatterjea Devavani, Clouthier David E, Yanagisawa Masashi M, Tsai Mindy, Galli Stephen J
Abstract excerpt
Endothelin-1 (ET-1) is a 21-amino-acid peptide, derived from vascular endothelial cells, with potent vasoconstrictor activity. ET-1 has been implicated in diverse physiological or pathological processes, including the vascular changes associated with sepsis. However, the factors that regulate ET-1-associated toxicity during bacterial infections, or in other settings, are not fully understood. Both the pathology...
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