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Article

Information dynamics in carcinogenesis and tumor growth.

Mutation research - 21 Dec 2004

Gatenby Robert A, Frieden B Roy

Abstract excerpt

The storage and transmission of information is vital to the function of normal and transformed cells. We use methods from information theory and Monte Carlo theory to analyze the role of information in carcinogenesis. Our analysis demonstrates that, during somatic evolution of the malignant phenotype, the accumulation of genomic mutations degrades intracellular information. However, the degradation is constrained...

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Identifiers

PMID: 15542113
DOI: 10.1016/j.mrfmmm.2004.04.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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