Article
Application of information theory and extreme physical information to carcinogenesis.
Cancer research - 1 Jul 2002
Gatenby Robert A, Frieden B Roy
Abstract excerpt
Cellular information dynamics during somatic evolution of the malignant phenotypes are complex and poorly understood. Accumulating, random genetic mutations and, therefore, loss of genomic information appears necessary for carcinogenesis. However, additional control parameters can be inferred because unconstrained mutagenesis would ultimately produce cellular information degradation incompatible with life....
Topics
- Animals
- Cell Division
- Humans
- Information Theory
- Models, Biological
- Mutation
- Neoplasms