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Article

The two cytochrome c species, DC3 and DC4, are not required for caspase activation and apoptosis in Drosophila cells.

The Journal of cell biology - 8 Nov 2004

Dorstyn Loretta, Mills Kathryn, Lazebnik Yuri, Kumar Sharad

Abstract excerpt

In Drosophila, activation of the apical caspase DRONC requires the apoptotic protease-activating factor homologue, DARK. However, unlike caspase activation in mammals, DRONC activation is not accompanied by the release of cytochrome c from mitochondria. Drosophila encodes two cytochrome c protein...

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Identifiers

PMID: 15533997
DOI: 10.1083/jcb.200408054
PMCID: PMC2172470

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15533997-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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