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Article

I kappaB alpha-independent downregulation of NF-kappaB activity by glucocorticoid receptor.

The EMBO journal - 1 Aug 1997

Heck S, Bender K, Kullmann M, Göttlicher M, Herrlich P, Cato A C

Abstract excerpt

I kappaB alpha is an inhibitor protein that prevents nuclear transport-and activation of the transcription factor NF-kappaB. In acute inflammation, NF-kappaB is activated and increases the expression of several pro-inflammatory cytokine and chemokine genes. Glucocorticoids counteract this process. It has been proposed that the glucocorticoid-dependent inhibition of NF-kappaB activity is mediated by increased...

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Identifiers

PMID: 9303314
DOI: 10.1093/emboj/16.15.4698
PMCID: PMC1170096

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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