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Article

Effect of Treating Induced Mitochondrial Damage on Embryonic Development and Epigenesis

4 Nov 2004

Abstract excerpt

Germinal vesicle transplantation (GVT) has been proposed as a possible treatment to correct age-related oocyte aneuploidy caused by dysfunctional ooplasm. How healthy ooplasm regulates normal meiosis and subsequent development has yet to be elucidated, but impaired mitochondrial metabolism may be attributable to incomplete segregation of the oocyte chromosomes. In the present study, after ooplasmic mitochondrial...

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PMID: 15525817
DOI: 10.1095/biolreprod.104.032391

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