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Article

Time-lapse video microscopy analysis reveals astral microtubule detachment in the yeast spindle pole mutant cnm67.

Molecular biology of the cell - 1 Apr 2000

Hoepfner D, Brachat A, Philippsen P

Abstract excerpt

Saccharomyces cerevisiae cnm67Delta cells lack the spindle pole body (SPB) outer plaque, the main attachment site for astral (cytoplasmic) microtubules, leading to frequent nuclear segregation failure. We monitored dynamics of green fluorescent protein-labeled nuclei and microtubules over several cell cycles. Early nuclear migration steps such as nuclear positioning and spindle orientation were slightly affected,...

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Identifiers

PMID: 10749924
DOI: 10.1091/mbc.11.4.1197
PMCID: PMC14841

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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