Article
Resistance to collagen-induced arthritis in a nonhuman primate species maps to the major histocompatibility complex class I region.
The Journal of experimental medicine - 1 Apr 1992
Bakker N P, van Erck M G, Otting N, Lardy N M, Noort R C, 't Hart B A, Jonker M, Bontrop R E
Abstract excerpt
Type II collagen-induced arthritis (CIA) is an experimentally inducible autoimmune disorder that is, just like several forms of human arthritis, influenced by a genetic background. Immunization of young rhesus monkeys (Macaca mulatta) with type II collagen (CII) induced CIA in about 70% of the animals. One major histocompatibility complex (MHC) class I allele was present only in young animals resistant to CIA and...
Topics
- Alleles
- Animals
- Arthritis
- Autoimmune Diseases
- Chromosome Mapping
- Collagen
- Genes, MHC Class I
- Macaca mulatta
- Major Histocompatibility Complex
- T-Lymphocytes