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MHC-DRB alleles with amino acids Val11, Phe13, and the shared epitopes promote collagen-induced arthritis and a rapid IgG1 response in Filipino cynomolgus macaques.

HLA - 1 Jan 2024

Ishigaki Hirohito, Ito Sayaka, Sasamura Takako, Ishida Hideaki, Nakayama Misako, Nguyen Cong Thanh, Kinoshita Takaaki, Suzuki Shingo, Iwatani Chizuru, Tsuchiya Hideaki, Yamanaka Hisashi, Kulski Jerzy K, Itoh Yasushi, Shiina Takashi

Abstract excerpt

Macaques are useful animal models for studying the pathogenesis of rheumatoid arthritis (RA) and the development of anti-rheumatic drugs. The purpose of this study was to identify the major histocompatibility complex (MHC) polymorphisms associated with the pathology of collagen-induced arthritis (CIA) and anti-collagen IgG induction in a cynomolgus macaque model, as MHC polymorphisms affect the onset of CIA in...

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PMID: 38226402
DOI: 10.1111/tan.15316

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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