Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tumor cells resistant to a microtubule-depolymerizing hemiasterlin analogue, HTI-286, have mutations in alpha- or beta-tubulin and increased microtubule stability.

Biochemistry - 9 Nov 2004

Poruchynsky Marianne S, Kim Jong-Hyeok, Nogales Eva, Annable Tami, Loganzo Frank, Greenberger Lee M, Sackett Dan L, Fojo Tito

Abstract excerpt

Hemiasterlins are sponge-derived tripeptides that inhibit cell growth by depolymerizing existing microtubules and inhibiting microtubule assembly. Since hemiasterlins are poor substrates for P-glycoprotein, they are attractive candidates for cancer therapy and have been undergoing clinical trials...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylation
Share to Cold Temperature
Share to Growth Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microtubules

Share to Oligopeptides

Share to Paclitaxel

Share to Tubulin

Share to Tyrosine

Source

Identifiers

PMID: 15518543
DOI: 10.1021/bi049300+

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15518543-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Tumor cells resistant to a microtubule-depolymerizing hemiasterlin analogue, HTI-286, have mutations in alpha- or beta-tubulin and increased microtubule stability.PMID 15518543Read ↗

Cells resistant to HTI-286 do not overexpress P-glycoprotein but have reduced drug accumulation and a point mutation in alpha-tubulin.Semantic proximity Read ↗

Mutations in alpha- and beta-tubulin that stabilize microtubules and confer resistance to colcemid and vinblastine.Semantic proximity Read ↗

Paclitaxel-resistant human ovarian cancer cells have mutant beta-tubulins that exhibit impaired paclitaxel-driven polymerization.Semantic proximity Read ↗

Amino acid substitutions at proline 220 of beta-tubulin confer resistance to paclitaxel and colcemid.Semantic proximity Read ↗

A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells.Semantic proximity Read ↗

Intra-allelic suppression of a mutation that stabilizes microtubules and confers resistance to colcemid.Semantic proximity Read ↗

Microtubule alterations and resistance to tubulin-binding agents (Review)Semantic proximity Read ↗

Mutations at leucine 215 of beta-tubulin affect paclitaxel sensitivity by two distinct mechanisms.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.