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Article

Suppression of wild-type rhodopsin maturation by mutants linked to autosomal dominant retinitis pigmentosa.

The Journal of biological chemistry - 14 Jan 2005

Rajan Rahul S, Kopito Ron R

Abstract excerpt

Autosomal dominant retinitis pigmentosa (ADRP) has been linked to mutations in the gene encoding rhodopsin. Most RP-linked rhodopsin mutants are unable to fold correctly in the endoplasmic reticulum, are degraded by the ubiquitin proteasome system, and are highly prone to forming detergent-insoluble high molecular weight aggregates. Here we have reported that coexpression of folding-deficient, but not...

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Identifiers

PMID: 15509574
DOI: 10.1074/jbc.M406448200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Suppression of wild-type rhodopsin maturation by mutants linked to autosomal dominant retinitis pigmentosa.PMID 15509574Read ↗

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