Article
A single bifunctional UDP-GlcNAc/Glc 4-epimerase supports the synthesis of three cell surface glycoconjugates in Campylobacter jejuni.
The Journal of biological chemistry - 11 Feb 2005
Bernatchez Stéphane, Szymanski Christine M, Ishiyama Noboru, Li Jianjun, Jarrell Harold C, Lau Peter C, Berghuis Albert M, Young N Martin, Wakarchuk Warren W
Abstract excerpt
The major cell-surface carbohydrates (lipooligosaccharide, capsule, and glycoprotein N-linked heptasaccharide) of Campylobacter jejuni NCTC 11168 contain Gal and/or GalNAc residues. GalE is the sole annotated UDP-glucose 4-epimerase in this bacterium. The presence of GalNAc residues in these carbohydrates suggested that GalE might be a UDP-GlcNAc 4-epimerase. GalE was shown to epimerize UDP-Glc and UDP-GlcNAc in...
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