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Article

Hepatitis C virus down-regulates insulin receptor substrates 1 and 2 through up-regulation of suppressor of cytokine signaling 3.

The American journal of pathology - 1 Nov 2004

Kawaguchi Takumi, Yoshida Takafumi, Harada Masaru, Hisamoto Takao, Nagao Yumiko, Ide Tatsuya, Taniguchi Eitaro, Kumemura Hiroto, Hanada Shinichiro, Maeyama Michiko, Baba Shinji, Koga Hironori, Kumashiro Ryukichi, Ueno Takato, Ogata Hisanobu, Yoshimura Akihiko, Sata Michio

Abstract excerpt

The pathogenesis of hepatitis C virus (HCV)-associated insulin resistance remains unclear. Therefore, we investigated mechanisms for HCV-associated insulin resistance. Homeostasis model assessment for insulin resistance was increased in patients with HCV infection. An increase in fasting insulin levels was associated with the presence of serum HCV core, the severity of hepatic fibrosis and a decrease in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15509521
DOI: 10.1016/S0002-9440(10)63408-6
PMCID: PMC1618659

Genes

IRS2
IRS1
SOCS3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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